In the following you will find a selection of publications about PentraSorb® CRP and about the pathological action of CRP sorted by topic.


Basic Background

Biomedicines 2023, 11(8), 2279. doi: 10.3390/biomedicines.11082279.
Being Eaten Alive: How Energy-Deprived Cells Are Disposed of, Mediated by C-Reactive Protein — Including a Treatment Option
Sheriff A, Kunze R, Brunner P, Vogt B.

Front. Immunol. 2023 Jul 26:1237729. doi: 10.3389/fimmu.2023.1237729.
C-reactive protein: a target for therapy to reduce inflammation
Rizo-Téllez SA, Sekheri M, Filep JG.

J. Clin. Med. 2022; 11(13), 3610. doi: 10.3390/jcm11133610
Special Issue “C-Reactive Protein and Cardiovascular Disease: Clinical Aspects”.
Sheriff A.

Ärzteblatt M-V. 4/2022.
C-reaktives Protein – Entzündungsmarker, Nekrosetrigger und therapeutisches Target.
Kunze R, Espsito F.

J. Clin. Med. 2022; 11,1771. doi: 10.3390/jcm11071771
Targeting C-Reactive Protein by Selective Apheresis in Humans: Pros and Cons.
Torzewski J, Brunner P, Ries W, Garlichs C D, Kayser S, Heigl F, Sheriff A.

Medizinische Klinik – Intensivmedizin und Notfallmedizin. 2022 Mar 28. doi: 10.1007/s00063-022-00911-x.
CRP-Apherese bei akutem Myokardinfarkt bzw. COVID-19.
Buerke M, Sheriff A, Garlichs C.D.

Front. Immunol. 2021 Feb 12:630430. doi: 10.3389/fimmu.2021.630430.
C-reactive Protein Triggers Cell Death in Ischemic Cells
Sheriff A, Kayer S, Brunner P, Vogt B.

Front. Immunol. 2020 Aug 28:11. doi: 10.3389/fimmu.2020.01978
C-reactive Protein causes Blood Pressure Drop in Rabbits and induces Intracellular Calcium Signaling
Bock C, Vogt B, Mattecka S, Yapici G, Brunner P, Fimpel S, Unger JK, Sheriff A.

Ther Apher Dial. 2019 Dec;23(6):494-496. doi: 10.1111/1744-9987.12802.
C-Reactive Protein: From Biomarker to Trigger of Cell Death?
Kunze, R.

Ther Apher Dial. 2019 Oct;23(5):474-481. doi: 10.1111/1744-9987.12796. Epub 2019 Mar 21.
PentraSorb C-Reactive Protein: Characterization of the Selective C-Reactive Protein Adsorber Resin.
Mattecka S, Brunner P, Hähnel B, Kunze R, Vogt B, Sheriff A.

Front Immunol. 2018 Jun 12;9:1351. doi: 10.3389/fimmu.2018.01351.
Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes.
McFadyen JD, Kiefer J, Braig D, Loseff-Silver J, Potempa LA, Eisenhardt SU, Peter K.

Circulation 2014 Apr 28;130:35–50. doi: 10.1161/CIRCULATIONAHA.113.007124.
Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation.
Thiele JR, Habersberger J, Braig D, Schmidt Y, Goerendt K, Maurer V, Bannasch H, Scheichl A, Woollard KJ, Dobschütz E, Kolodgie F, Virmani R, Stark B, Peter K, Eisenhardt SU.


J. Clin. Med. 2022; 11,1956. doi: 10.3390/jcm11071956
Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis.
Esposito F, Matthes H, Schad F.

Am J Case Rep. 2021 Dec 30. In Press: DOI: 10.12659/AJCR.935263
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV) Registry.
Schumann C, Heigl F, Rohrbach I, Sheriff A, Wagner L, Wagner F, Torzewski J.

Front. Immunol. 12:708101. doi: 10.3389/fimmu.2021.708101
Case Report: C- Reactive Protein Apheresis in a Patient With COVID-19 and Fulminant CRP Increase.
Ringel J, Ramlow A, Bock C and Sheriff A.

Am J Case Rep. 2021 Jul 27: 22: e932964. doi: 10.12659/AJCR.932964
Successful Treatment of a 39-Year-Old COVID-19 Patient with Respiratory Failure by Selective C-Reactive Protein Apheresis.
Torzewski J, Zimmermann O, Kayser S, Heigl F, Wagner F, Sheriff A, Schumann C.

Eur Heart J. 2021 Mar 29: ehab169, doi: 10.1093/eurheartj/ehab169
C-reactive protein predicts outcome in COVID-19: is it also a therapeutic target?.
Pepys MB.

Eur Heart J. 2021 Jan 21: ehaa1103. doi: 10.1093/eurheartj/ehaa1103
C-reactive protein and clinical outcomes in patients with COVID-19.
Smilowitz NR, Kunichoff D, Garshick M, Shah B, Pillinger M, Hochman JS, Berger JS.

Cell Rep Med. 2020 Nov 17: 1;8. doi: 10.1016/j.xcrm.2020.100144
Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients.
Mueller AA, Tamura T, Crowley CP, DeGrado JR, Haider H, Jezmir JL, Keras G, Penn EH, Massaro AF, Kim EY.

MedPage Today 2020 Jul 27
Apheresis gets Tryout in COVID-19
Kate Kneisel

Am J Case Rep. 2020 Jul 14:21:e925020. doi: 10.12659/AJCR.925020
First-in-Man: Case Report of Selective C-Reactive Protein Apheresis in a Patient with SARS-CoV-2 Infection.
Torzewski J, Heigl F, Zimmermann O, Wagner F, Schumann C, Hettich R, Bock C, Kayser S, Sheriff A.

Ther Apher Dial. 2020 Jun 05. doi: 10.1111/1744-9987.13532
Selective C-reactive protein apheresis for Covid-19 patients suffering from organ damage.
Kayser S, Kunze R, Sheriff A.