11.01.2022
The authors of the review article “Immune Mechanisms of Plaque Instability” from the Charité Cardiology Department describe the Pentracor CAMI-1 study “CRP apheresis in Acute Myocardial Infarction” as groundbreaking.
Excerpt from the article:
"The investigators of the recently published “CRP apheresis in Acute Myocardial Infarction (CAMI-1)” study moved downstream of IL-6 in the inflammatory cascade, directly targeting the inflammatory marker high-sensitivity C-reactive protein (hsCRP) (16). In this non-randomized pilot study, 66 patients with acute ST-elevation-MI were treated with repeated CRP-aphereses. On the one hand, the study demonstrates a correlation between the systemic CRP level, the extent of myocardial damage and the restriction of myocardial function. On the other hand, it introduces CRP-apheresis as an interesting and safe, but technically challenging method to target direct detrimental effects of CRP after acute MI.
These landmark trials have launched a thrilling new era of treatment in Cardiovascular Disease."
Gerhardt T, Haghikia A, Stapmanns P and Leistner DM (2022) Immune Mechanisms of Plaque Instability. Front. Cardiovasc. Med. 8:797046. doi: 10.3389/fcvm.2021.797046
The entire CAMI-1 study can be found at this link.
Den Review Artikel „Immune Mechanisms of Plaque Instability“ finden Sie here.
