In the scientific journal Frontiers in Immunology an article was published in which the effect of human CRP on blood pressure and heart rate of rabbits was investigated.

The results show for the first time a rapid and strong reduction of blood pressure after injection with CRP without counterregulation of the heart rate. Furthermore, CRP induces intracellular calcium mobilization, implying a direct effect on gene activation. This effect is of particular interest in the context of difficult-to-control hemodynamic parameters, which often occur in patients with large inflammatory events (e.g., sepsis, cardiac arrest, polytrauma). In these, the CRP concentration is also very high. A precise correlation as well as the molecular mechanism behind this are being further investigated.