Today a new paper has been published in the Journal of Clinical Medicine. It is a further analyses of our CAMI-1 study. In figure 1 you can see the observation of a correlation between ejection fraction of LVEF and size of infarct area that has never been described in literature: LVEF is only effected if the infarct area is more than 22%.
The area of infarction of the control group is greater than 22 % in both, the first and second MRI (CMR1 and CMR2 ~ 5 days and 88 days post-infarction, respectively). However, in the intervention group CMR1 and CMR2 showed a smaller size of infarction with 22.5 % and 18.1%, respectively. This resulted in a normal LVEF for the intervention group (apheresis).
This advantage of infarction size reduction and overall normalized LVEF remained after 3 months post-intervention with a trend of continuous recovery.
Table 3 showcases the C-reactive protein (CRP) dependent effect on size of cardiac infarction and LVEF.
The paper was chosen by the Editorial Board of the journal to be a feature paper: "meaning it is of particular interest to our readers".
Link to the publication: doi.org/10.3390/jcm11216446